Well to be honest I rather hope his performance on Q was just the result of too many substances, only if not it sounds rather like PSP which Dudley Moore had.
("In 1987, Dudley Moore enlisted music critic Renata Fruchter as an artistic partner and they performed as a duo in the U.S. and Australia. However, his disease soon started to make itself apparent as his fingers would not always do what he wanted them to do. Symptoms such as slurred speech and loss of balance were interpreted by the public and the media as a sign of drunkenness. Dudley Moore himself was at a loss to explain this.
On 30 September 1999, Moore announced that he was suffering from the terminal degenerative brain disorder Progressive Supranuclear Palsy. wikipedia).
PSP symptoms include loss of balance, slurred speech and vision focus problems. In particular moving the eyes, particularly in the vertical direction. The latter accounts for some of the falls experienced by these patients as they are unable to look up or down.
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